Hye-Ji Kim et al. explore the cellular mechanisms underlying cortisol-induced cognitive impairment in rat pups whose mothers received repeated injections of CORT during pregnancy and reported that the expression of the NR2B subunit in the hippocampus of the rat pups was relatively high and the expression levels of PSD-95 and BDNF were relatively low [40]. The gene discussed is BDNF; the disease is Cognitive impairment.