INS and type 2 diabetes mellitus: Even though clinical trials on CBD are still limited, a Phase I study investigating the efficacy of a sublingual CBD/THC regimen (10:1) in type 2 diabetes patients found significant improvements in fasting blood sugar, HbA1c, and 2 h Oral Glucose Tolerance Test (OGTT) values, along with reduced insulin secretion and HOMA2-IR values, suggesting that CBD may enhance insulin sensitivity and glycemic control [11].