Vitexin, found in the traditional Chinese herb Crataegus pinnatifida (hawthorn), has been shown to induce apoptosis through the mitochondrial pathway by lowering the Bcl-2/Bax ratio and increasing the expression of cleaved caspase-3 in human non-small cell lung cancer A549 cells [37]. This evidence concerns the gene CASP3 and non-small cell lung carcinoma.