Additionally, interference with cell signaling pathways, including the glycogen synthase kinase-3β (GSK-3β)/β-catenin, phosphoinositide 3-kinase (PI3K)/protein kinase B (PKB, Akt), and mitogen-activated protein kinase (MAPK) pathway, plays an important role in cancer development and progression [19,20,21]. The gene discussed is AKT1; the disease is cancer.