INS and Insulin resistance: Activation of CB1 receptors in the liver can lead to increased glucose secretion into the blood (gluconeogenesis) [38], which can contribute to elevated blood glucose levels (hyperglycemia), while activation of CB1 receptors in peripheral tissues (such as muscles and adipose tissue) can reduce tissue sensitivity to insulin, leading to the development of insulin resistance and significantly increasing the risk of type 2 diabetes [15,26,39].