However, elevated levels of cardiac biomarkers (B-type natriuretic peptide, BNP ≥ 35 pg/mL, or N-terminal pro-B-type natriuretic peptide, NT-proBNP ≥ 125 pg/mL) or persistently elevated high-sensitivity cardiac troponin levels (troponin T ≥ 14 ng/l for women and ≥22 ng/l for men, or troponin I ≥ 10 ng/l for women and ≥12 ng/l for men), as well as functional or structural heart abnormalities proved by echocardiography are now diagnostic criteria for subclinical HF [60]. The gene discussed is NPPB; the disease is hydrops fetalis.