In this regard, Hernández et al. demonstrated a significantly higher prevalence of aPL in RVO patients compared with controls (10% vs. 4.3%; adjusted OR 2.47, p = 0.009), reinforcing the hypothesis that acquired thrombophilia, particularly APS, may contribute to the pathogenesis of RVO [20]. This evidence concerns the gene FASLG and autoimmune polyendocrinopathy.