PIM1 and urea cycle disorder: These studies emphasize that genes affecting chromatin organization and abnormalities in methylation (such as SETD1A, ASH1L, KMT2E, and DNMT3A) are more prevalent in iMCD [42,43], while abnormalities in interleukin signaling pathways (PDGFRB, FGFR3, NF1, PIM1, PTPN6, IL6ST) occur more frequently in UCD [40,43].