Singh reported a 37-year-old alcoholic with acute heart failure, an NT-proBNP level of 4921 ng/L, moderate renal insufficiency, sinus tachycardia at 117 bpm, elevated blood pressure, and a left ventricular ejection fraction of 25% without signs of coronary artery disease [11]. The gene discussed is NPPB; the disease is coronary artery disorder.