Familial MM can be associated with genetic syndromes such as Neurofibromatosis type 2 (NF-2), Cowden syndrome, Multiple Endocrine Neoplasia 1 (MEN1), Werner syndrome, Rubinstein–Taybi syndrome, Gorlin syndrome, and Li–Fraumeni syndrome [7,11,24,25,26,27,28,29,30,31] (Table 4). Here, NF2 is linked to Cowden disease.