High levels of estrogen have been reported to increase the expression of Beta-galactoside alpha-2,6-sialyltransferase 1 (ST6GAL1), the enzyme responsible for sialic acid binding to IgG, thereby increasing IgG sialylation and possibly inducing an anti-inflammatory effect in RA patients [58]. The gene discussed is ST6GAL1; the disease is rheumatoid arthritis.