NFKB1 and cancer: Moreover, blockade of B1/B2-adrenoceptors was found to suppress pancreatic cancer cell proliferation and invasion by inducing apoptosis and by inhibiting the expression of NF-kB, AP-1 and CREB, as well as the expression of MMP-9, MMP-2, and VEGF target genes [33], all of which are pivotal for cancer management by propranolol.