Individuals with PWS (MetS+) showed higher fasting glucose (+11.8%, p < 0.05), Hb1Ac (+10.2%, p < 0.05), HOMA-IR (+44.8%, p < 0.05) and triglycerides (+44.1%, p < 0.05) levels, and lower HDL-cholesterol (−20.1%, p < 0.05) than individuals with PWS (MetS−), while no significant differences were recorded in fasting insulin or total- and LDL-cholesterol levels between the two subgroups (Table 4). This evidence concerns the gene INS and Prader-Willi syndrome.