Subjects with PWS (MetS+) showed lower fasting insulin (−27.9%, p < 0.05), higher fasting glucose (+12.1%, p < 0.05), Hb1Ac (+12.1%, p < 0.05) and the same HOMA-IR than subjects with EOB (MetS+) (Table 4). The gene discussed is INS; the disease is metabolic syndrome.