GH1 and Hypertension: The response of cardiomyocytes and vascular tissues to physiological stimuli (e.g., insulin, catecholamines, fatty acids) and pathological stresses (e.g., ischemia-reperfusion, arterial hypertension) is modulated by peripheral clocks via transcription–translation loops involving growth factors (i.e., growth hormone, GH; insulin-growth factor, IGF) and metabolic biomarkers (substrates and enzymes of glycolysis and the Krebs cycle) [25].