Similarly, blocking ICOS activity with anti-B7RP-1 antibody (anti-B7RP-1 Ab) in a New Zealand Black/New Zealand White (NZB/NZW) F(1) mouse model of systemic lupus erythematosus led to a reduction in Tfh and gcB cells, which was accompanied by an improvement in disease manifestations [40,41]. Here, ICOSLG is linked to systemic lupus erythematosus.