According to a study conducted with E. agallocha in A549 and H1299 (human lung cancer) cell lines, western blot analysis of Bcl-2, Bax, p53, p21, and PARP (Poly (ADP-Ribose) Polymerase) gene expression revealed that p21 was significantly upregulated in both cell lines, and apoptosis of A549 cells led to significant upregulation of the p53 gene. Here, BCL2 is linked to lung cancer.