SCN9A and Pain: In addition, pharmacological inhibition of CRMP2 phosphorylation, as well as blocking the domain responsible for the interaction between CRPM2 and Nav1.7, decreases Nav1.7 membrane localization and function in the DRG, leading to the reversal of mechanical allodynia following intrathecal administration in the SNI model of chronic neuropathic pain [128,134,135].