The causes of anemia in heart failure include (1) hemofiltration due to fluid retention, (2) decreased erythropoietin production due to chronic kidney disease, (3) decreased bone marrow hematopoietic function due to inflammatory cytokine activity stimulation, (4) iron deficiency, etc. [5], but there is no established evidence on how to treat anemia. This evidence concerns the gene EPO and anemia (phenotype).