Furthermore, evidence suggests a positive association between resistin levels and inflammatory markers such as IL-6, soluble tumor necrosis factor receptor 2 (Sol TNF-R2), and lipoprotein-associated phospholipase A2 (Lp-PLA2), as well as increased coronary artery calcification in both healthy individuals and those with T2D [29]. This evidence concerns the gene TNFRSF1B and type 2 diabetes mellitus.