From the clinical perspective, multiple clinical studies have investigated the role of resistin as a contributing factor in hypertension, atherosclerosis, coronary heart disease (CHD), acute myocardial infarction (AMI), and heart failure, and as an indicator of severe myocardial damage, poor prognosis, and a predictor of cardiovascular mortality in T2D. The gene discussed is RETN; the disease is hypertensive disorder.