KEAP1 and Huntington disease: Based on evidence of a resveratrol-dependent blockage of Keap1 and its neuroprotective effects showed in preclinical research using 3-NPA-induced models using male C57BL/6J mice, 3-NPA-treated rats, and N171-82Q transgenic mice, a clinical investigation evaluated resveratrol’s effect on caudate volume in HD patients (ID: NCT02336633).