He et al. reported that many kinds of natural medicine except RKT may treat osteoporosis by their the anabolic and anticatabolic effects via the signaling pathway of classical Wnt/β-catenin, TGF-β/Smad, BMP2, Notch, RANKL, MAPK, and NFATc1 families [38]. The gene discussed is NFATC1; the disease is osteoporosis.