The observed trend toward increasing effect sizes in vWF levels over time, as shown in the cumulative meta-analyses—both in Plasmodium-infected individuals compared to uninfected controls and in severe compared to less severe malaria cases—may be influenced by advancements in laboratory techniques and increased standardization of vWF quantification methods (e.g., improved ELISA sensitivity and assay calibration) in recent years. Here, VWF is linked to malaria.