A functional annotation of the 120 proteins indicated that 10 pathways were significantly affected in tumor tissues: the immune system (p = 1.200 × 10−42), innate immune system (p = 4.878 × 10−41), neutrophil degranulation (p = 2.129 × 10−22), regulation of complement cascade (p = 5.361 × 10−17), complement cascade (p = 2.059 × 10−16), cytokine signaling in immune system (p = 8.811 × 10−14), activation of C3 and C5 (p = 2.863 × 10−13), interferon signaling (p = 9.786 × 10−13), antimicrobial peptides (p = 2.719 × 10−10), and terminal pathway of complement (p = 3.946 × 10−10). The gene discussed is C5; the disease is neoplasm.