Materials and Methods: In this study, comparisons were made between serum levels of asprosin and neuregulin 4, along with various anthropometric, biochemical, and hormonal parameters associated with obesity, among 40 children with obesity and 40 children with normal weight who sought medical attention at the Child Health and Diseases outpatient clinic of Kırşehir Training and Research Hospital between September 2021 and September 2022. This evidence concerns the gene NRG4 and obesity due to melanocortin 4 receptor deficiency.