Proteomics analysis has identified several potential biomarkers with specificity for PSP, CBS, or both, including Wnt-1, ATP6AP2, and other targets implicated in glycan synthesis, cholesterol metabolism, and cell adhesion, potentially yielding valuable insights into the largely unknown pathogenesis of these multifactorial diseases [92,93]. This evidence concerns the gene ATP6AP2 and supranuclear palsy, progressive, 1.