TARDBP and amyotrophic lateral sclerosis: Furthermore, Saijo and co-authors employed real-time quaking-induced conversion (RT-QuIC) assays on post-mortem CSF and crude brain homogenates from patients with diverse neurodegenerative conditions, including various forms of FTD, such as PSP, CBD, Pick’s disease, amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration with TDP-43 (FTLD-TDP), and frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) [28].