PCSK9 and familial hypercholesterolemia: Several medication options are currently available for the management of hypercholesterolemia—the first line of treatment is statins (hydroxy-methyl-glutaryl-coenzyme A (HMG-CoA) reductase inhibitors), while adding ezetimibe and Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are recommended when target LDL-c levels cannot be reached with statins alone [19].