ACE2 and diabetes mellitus: Regarding diabetes, apart from the endothelial damage, the study by Muniyappa R and Gubbi S have suggested several other mechanisms: hyperglycemia induced inhibition of intracellular destruction of microbes, neutrophil chemotaxis, and phagocytosis providing higher affinity for cellular binding and effective virus entry, and reducing viral clearance [7,22] Furthermore, it is believed that SARS-CoV-2 uses ACE2 as entry receptors.