CD4 and neoplasm: Zou et al. used the S180 sarcoma mouse model as their research object to observe the ex vivo and in vivo antitumor effects of COPs and their modulatory effects on CD4+ T cells, CD8+ T cells, interleukin IL-2, and interleukin IL-4 in the peripheral blood of the loaded tumor-bearing mice and compared them with those of the negative control group.