STX2 and hemolytic-uremic syndrome: For example, Shiga toxin-producing E. coli (STEC), which carries a Shiga toxin (Stx-)-related gene, can develop mutations that result in the production of Stx1a-, Stx1c-, Stx2a-, Stx2c-, Stx2d-, etc. Similar to Stx2a- and Stx2c-, the Stx2d-variant may be associated with the development of hemorrhagic colitis and hemolytic uremic syndrome, but there were not many reports of this variant’s existence in STEC strains.