MTDH and glioblastoma: In glioblastoma cells, cytoplasmic polyadenylation element binding protein 1 (CPEB1) increases AEG-1 translation by binding to its mRNA, while in HCC cells CPEB3 inhibits AEG-1 translation by binding to the 3′-untranslated region of AEG-1 mRNA [60,61].