Given AEG-1′s role in regulating the activation of macrophages [82], which play a central role in regulating HCC [171], inhibiting AEG-1 in both HCC cells and tumor-associated macrophages (TAMs) using targeted nanoparticle-delivered AEG-1 siRNA might be a potential approach for HCC treatment. Here, MTDH is linked to hepatocellular carcinoma.