On the other hand, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (Pik3ca) overexpression in mouse hepatocytes generates steatosis and HCC, while deletion of Akt2 from mouse hepatocytes leads to the accumulation of triglycerides (TG) in the liver. The gene discussed is PIK3CA; the disease is hepatocellular carcinoma.