The overexpression of AEG-1 or SND1 augmented RISC activity with a resultant increased degradation of tumor-suppressor mRNAs targeted by oncogenic miRNAs, e.g., there was downregulation of PTEN which is a target of miR-221, an oncogene for HCC [73]. The gene discussed is PTEN; the disease is hepatocellular carcinoma.