A hepatocyte-specific AEG-1 transgenic mouse (Alb/AEG-1) spontaneously developed MASH and a hepatocyte-specific conditional AEG-1 knockout mouse (AEG-1ΔHEP) was protected from high fat diet (HFD)-induced MASH [48]. The gene discussed is MTDH; the disease is metabolic dysfunction-associated steatohepatitis.