W394 and W401 were identified as key residues of AEG-1 interacting with SND1, and the crystal structure of the AEG-1/SND1 interaction region was resolved, paving the way for developing small molecule inhibitors that perturb this interaction, inhibit AEG-1, and serve as anti-cancer agents [75,76,77,78]. The gene discussed is MTDH; the disease is cancer.