A small molecule compound library screening identified a number of compounds inhibiting AEG-1/SND1 interaction, of which the prototype molecule C26-A6 inhibited tumor growth and metastasis and enhanced sensitivity to paclitaxel and anti-PD-1 antibody in in vivo models of triple-negative breast cancer using 4TO7 cells and Balb/c mice [76,77]. The gene discussed is SND1; the disease is triple-negative breast carcinoma.