MTDH and central nervous system cancer: Although AEG-1 has been implicated in positively regulating glutamate transporter (excitatory amino acid transporter 2; EAAT2) expression in the context of glioma [83], no behavioral abnormality was observed in AEG-1−/− mice suggesting that neurotransmitter regulation in the brain may not be a physiological function of AEG-1 [81].