Apart from male infertility, AEG-1−/− mice do not show any developmental abnormality [79,81], and their leanness has been attributed predominantly to an abnormality in fat absorption from the intestines [80], suggesting that AEG-1 inhibition may not have any significant adverse effect on normal cells, especially when used to treat cancers in adult individuals. The gene discussed is MTDH; the disease is male infertility.