While on its own, AEG-1 showed high sensitivity and low specificity and accuracy, and GPC3 showed high specificity but low sensitivity and accuracy; together, sensitivity, specificity, and accuracy reached 94.6%, 89.5%, and 90.5%, respectively, suggesting that this combination might be used as diagnostic markers for biopsy samples in HCC [146]. This evidence concerns the gene GPC3 and hepatocellular carcinoma.