Hepatocyte-specific conditional Miz1 knockout mice were more susceptible to DEN- and MASH-induced HCC, and single-cell RNA-sequencing (scRNA-seq) of the livers of these mice identified a subset of hepatocytes with hyperactivation of NF-κB, which facilitated the polarization of tumor-infiltrating macrophages toward the pro-inflammatory M1 phenotype, thereby promoting liver inflammation [124]. Here, ZBTB17 is linked to hepatocellular carcinoma.