PBRM1 and nonpapillary renal cell carcinoma: For example, the TRACERx study defined seven major clonal subtypes of ccRCC based on genetic alterations: VHL mono-driver, PBRM1-SETD2, PBRM1-somatic copy number alteration (SCNA), PBRM1-PI3K, VHL wildtype, multiple clonal driver, and BAP1 driven [7].