Expression of this factor can contribute to the resistance mechanism by improving the tumor’s vascular supply and promoting a more aggressive cancer phenotype and expression of Angiopoietin 2 (ANG-2), which is known to promote tumor growth by stimulating the formation of new blood vessels that help to sustain tumour growth and protect the tumor microenvironment from chemotherapy-induced damage [13,15]. The gene discussed is ANGPT2; the disease is neoplasm.