Regardless, our case designation of AML-MR was based on the presence of a constellation of genetic lesions, other than RUNX1, agreed upon by both the ICC and WHO classifications as myelodysplasia-related (i.e., myelodysplasia-related somatic mutations in cases A, B, E, F, G, and H; complex karyotypes in cases K, L, N, and O; monosomy 7 in case P). Here, RUNX1 is linked to acute myeloid leukemia.