In addition to its oncogenic role in acute myeloid leukemia (AML) associated with t(8;21)(q22;q22)/RUNX1::RUNX1T1 fusion, RUNX1 aberrations have been implicated in other subtypes of AML and myelodysplastic neoplasms (MDSs) [1]. The gene discussed is RUNX1; the disease is myelodysplastic syndrome.