Lastly, we found that cases of pDC-AML were enriched for mutations implicated in clonal hematopoiesis and myelodysplasia, including mutations in genes affecting epigenetic regulation (TET2 and DNMT3A), histone modification (ASXL1 and EZH2), splicing factors (SRSF2 and SF3B1), signal transduction (NRAS, CBL, and PTPN11) and nucleosome assembly (RUNX1), refs. [8,9] as well as other variants, distinguishing it from MPAL-B/myeloid. The gene discussed is CBL; the disease is acute myeloid leukemia.