Among these, cyclin-dependent kinase 1 (CDK1), polo-like kinase 1 (PLK1), and aurora kinase A (AURKA) exhibited dramatically increased transcriptional expression in HB patients compared to non-cancerous liver samples, suggesting a pivotal role as HSP90 clients in maintaining cell cycle activity in HB (Figure 4E). Here, CDK1 is linked to hemoglobin measurement.