CD4 and neoplasm: Several tumor promoting mechanisms are potentially linked to G-CSF and its receptor, such as the increased proliferation and migration of cancer cells, tumor neo-angiogenesis, deprived adaptive immune responses through IFNγ and IL-17 dependent mechanisms and reduction in the infiltration of CD4+ and CD8+ T cells into the tumor microenvironment (TME) [5,6,7,8].