In this study, there were 17 evaluable patients with refractory, recurrent, or metastatic sarcomas (osteosarcoma, Ewing sarcoma, primitive neuroectodermal tumor, desmoplastic round cell tumor) treated with HER2-directed CAR T-cells without any pre-infusion lymphodepleting chemotherapy. The gene discussed is ERBB2; the disease is osteosarcoma.