It was found that the PD-L1 mRNA level is elevated both in DLBCL without BM involvement and in DLBCL with BM involvement in comparison with NCBD (p < 0.05); mRNA levels of TIMP1, TOP2A, and TP53 proved to be lowered both in DLBCL without BM involvement and in DLBCL with BM involvement as compared to NCBD (p < 0.05) (Table 1). The gene discussed is CD274; the disease is diffuse large B-cell lymphoma.