N1-type neutrophils, characterized by their anti-tumor phenotype, exhibit hypersegmented nuclei and high expression levels of factors such as tumor necrosis factor-α (TNF-α), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and CCL3 [21]. This evidence concerns the gene CCL3 and neoplasm.