In conclusion, radioresistant PCa cells exhibited a hypoxic signaling environment characterized by the upregulation of HIF-1a (PC-3-R, p < 0.001; DU 145-R, p = 0.030; Myc-CaP-R, p = 0.003) and HIF-2a (PC-3-R, p < 0.001; DU 145-R, p = 0.034) compared to their parental PCa cells, resulting in reduced radiosensitivity (PC-3, p < 0.001; DU 145-R, p < 0.001; Myc-CaP-R, p < 0.001). This evidence concerns the gene HIF1A and posterior cortical atrophy.