HIST1H1A, HIST1H1B, HIST1H2AB, HIST1H2BB, HIST1H2BF, HIST1H3A, KAT2B, UHRF1, miR17HG and miR221 epigenetic regulators were selected from those 200 genes that showed the greatest difference in expression levels in the case of comparing vemurafenib-treated and untreated melanoma cells. This evidence concerns the gene H1-1 and melanoma.