Although no translational clinical applications of either JMJD6 or PHF6 in DLBCL have been established to date, JMJD6 is involved in the maintenance and multilineage differentiation potential of HSCs [66], while the oncogenic effect of PHF6 is suggested in precursor B-cell lymphoblastic leukemia [67] (Figure 3b). Here, PHF6 is linked to precursor B-cell acute lymphoblastic leukemia.