CGAS and hyperinsulinemic hypoglycemia, familial, 4: By leveraging murine MOC1 and MOC2 cell-derived tumors with differential dendritic cell and T-cell infiltration, our findings suggest that impaired DNA sensing through the cGAS-IFN-I signaling pathway in “immune-cold” HNSCC cells may contribute to antigen presentation dysfunction and DC deficiency, leading to immune evasion and therapeutic resistance to immunotherapy.