In particular, the main phytochemicals involved in the lncRNA modulation are curcumin and resveratrol that, restoring the expression of lncRNAs, e.g., H19, HOTAIR, and MALAT1, lead to the inhibition of cellular proliferation and motility in several cancer types: breast, glioma, gastric, renal, and colorectal. Here, HOTAIR is linked to central nervous system cancer.