The relationship between lncRNAs and the PD-1/PD-L1 pathway in melanoma is also confirmed in the study by Ding et al. The authors showed that the high level of LINC01214 promotes immunotherapy resistance through the regulation of the miR-4492/PPP1R11 axis, which induces the dysfunction of CD8+ T cells [95]. Here, CD274 is linked to melanoma.