To understand whether the deficiency of this protein triggers a kidney disease, the most updated version of gnomAD (v4.1.0) indicates that PODXL exhibits a slight deviation in loss intolerance probability [pLI = 0.27] and a moderate deviation in the observed/expected ratio of variation [o/e = 0.41 (0.29–0.6)], suggesting partial intolerance to loss-of-function (LoF) variants [4]. Here, PODXL is linked to kidney disorder.