Consequently, not only are the aforementioned highly penetrant genes tested, but also other high-to-moderate-penetrance genes (hereinafter, cancer-predisposing genes (CPGs)), such as PALB2, CHEK2, ATM, BRIP1, RAD50, RAD51C, and RAD51D, which are now routinely incorporated into genetic testing panels. The gene discussed is RAD50; the disease is cancer.