CD274 and acute myeloid leukemia: Upregulation of miR-34a led to reduced cell surface PD-L1 expression, inhibited PD-L1 surface expression induced by IFN-γ in AML cells (HL-60), inhibited apoptosis of PD-L1+/CD8+ T cells, and disrupted IL-10 production in AML cells treated with IFN-γ [103].