mRNA expression of CXCL9, iNOS, and IL-12β, anti-tumor macrophage markers, was elevated, while mRNA expression of IFNγ, TNFα, ARG-1, TGFβ, IL-10, and VEGFa, pro-tumor macrophage markers, was significantly lower in TAMs isolated from the prostates of RON∆Epi/TRAMP+ compared to RONF/F/TRAMP+ mice. The gene discussed is TGFB1; the disease is neoplasm.