TAMs help support the tumor in numerous ways, whether by pro-growth signaling, anti-inflammatory cytokine signaling to prevent other immune cells from killing the tumor, secretion of matrix metalloproteinases (MMPs) to break down the extracellular matrix, secretion of VEGF for angiogenesis, promotion of epithelial-to-mesenchymal transition (EMT) in tumor cells, or even extravasation through blood vessels to help tumors metastasize [9,10]. Here, VEGFA is linked to neoplasm.