In particular, lncRNA T-ALL-R-LncR1 is overexpressed in 11 out of 21 pediatric T-ALL patients [33], while the high expression of LUNAR1 is positively correlated with NOTCH1 and IGF-1R and with poor prognosis, which suggests its potential role as a prognostic biomarker [39]. Here, NOTCH1 is linked to acute lymphoblastic leukemia.