Compared to patients with type I procollagen defect caused by non-glycine substitutions, those with glycine substitutions exhibit more severe short statures (Z-score, −5.38 ± 4.36 vs. −2.49 ± 2.75; p < 0.001), scoliosis (27.1% vs. 12.9%, p = 0.025), and a later onset of fractures (6.79 ± 8.44 vs. 4.67 ± 5.68 years, p = 0.034) (Table 3). This evidence concerns the gene COL1A2 and scoliosis.