ALS-associated C21ORF2 mutants (V58L, R106C, R172W, A255T) exhibit reduced localization to centrosomes and diminished ability to rescue ciliogenesis defects in human neuroblastoma SH-SY5Y cells [52], suggesting that these proteins function at the centrosome to initiate ciliogenesis. Here, CFAP410 is linked to amyotrophic lateral sclerosis.