A recent finding that elevated TDP-43 levels in plasma extracellular vesicles distinguish ALS from other neurodegenerative disorders with high diagnostic accuracy [121] suggests the potential use of ALS-related proteins in plasma as biomarkers for assessing the state of ALS, although further studies are required to validate these biomarkers in preclinical stages. Here, TARDBP is linked to amyotrophic lateral sclerosis.