Mutations in the NEK1 gene have been associated with a variety of disorders, including short-rib polydactyly syndrome [35], axial spondylometaphyseal dysplasia (SMD) [36], frontotemporal dementia (FTD) with ALS [37], and ALS [37,38,39,40]. Here, NEK1 is linked to amyotrophic lateral sclerosis.