VCP and bone Paget disease: VCP mutations have been implicated in multisystem proteinopathy 1 (MSP1) (also known as inclusion body myopathy associated with Paget disease of bone and FTD) [75,76], Charcot-Marie-Tooth type 2 disease [77], Parkinson’s disease (PD) [78,79], hereditary spastic paraplegia [80], and ALS [81], with the latter condition added to the list in 2010.