TGFB1 and neoplasm: Another mechanism for immune escape is the recruitment of immunosuppressive cells like myeloid-derived suppressive cells, associated with inhibiting T cell activation and proliferation, as well as promoting regulatory T cell (Tregs) expansion; M2-like TAMs; N2 TANs; Tregs, which inhibit CTL and NK cell activity by secreting TGF-β and IL-10, maintaining the immunosuppressive TME; and tumor-associated DCs (tDCs), which usually have a tolerogenic phenotype, promote Treg expansion, and inhibit CTL activation [160].