Additionally, recent findings on estrogen receptors (ERs) in the female brain indicate that the ER-mediated activation of kinases, including Akt and TrkB, plays a role in cell differentiation, survival, apoptosis, and neurodegenerative processes, as well as mental health conditions such as depression, schizophrenia, and neurodegenerative diseases [60]. The gene discussed is ESR1; the disease is major depressive disorder.